Image by Mathew Schwartz

研究
Research

 

研究領域

疾病の疫学・診断・治療に関する臨床研究に加え、ヘルスサービス研究、ヘルスコミュニケーション研究、医学教育研究、行動科学研究など、幅広い研究課題に取り組んでいます。

特に医療の最前線であるにもかかわらず、エビデンスが不足しているプライマリ・ケア、総合診療/家庭医療領域のエビデンス構築は、当教室のメインテーマです。

主な研究課題

  • 多施設共同・在宅高齢者コホート構築と在宅死に関する研究

  • 患者複雑性に関する研究 

  • プライマリ・ケアの質評価に関する研究 

  • 多疾患併存状態 (Multimorbidity)に関する研究 

  • LGBTに関する研究

​など

2020年業績

  • Kaneko M, Aoki T【equally contributed】, Goto R, Ozone S, Haruta J. Better Patient Experience is Associated with Better Vaccine Uptake in Older Adults: Multicenterd Cross-sectional Study. J Gen Intern Med 2020 Sept 16. [Epub ahead print].

概要:全国多施設研究のデータを用い、65歳以上の高齢者を対象として、プライマリ・ケアの質指標の一つであるJapanese version of Primary Care Assessment Tool (JPCAT)とインフルエンザ及び肺炎球菌ワクチン接種との関連を報告しました。

  • Aoki T, Watanuki S Multimorbidity and patient-reported diagnostic errors in the primary care setting: multicentre cross-sectional study in Japan BMJ Open 2020;10:e039040.

概要:日本のプライマリ・ケア・セッティングで初めて、患者が報告する診断エラーを多施設で調査し、Multimorbidityと診断エラーとの関連を報告した研究です。

国外の同様調査と比較し、診断エラーの報告頻度は少なく、その原因として、ヘルスケアシステムの違い、診断エラーという概念の文化差などが仮説として挙げられました。

また国際的にもMultimorbidityと診断エラー(診断を限定しない)との関連を報告した初めての論文です。

  • Sugiyama Y, Matsushima M, Yoshimoto H Association between alcohol consumption/alcohol use disorders and patient complexity: a cross-sectional study BMJ Open 2020;10:e034665.

概要:単施設で実施した横断研究です。Alcohol Use Disorders Identification Test(AUDIT)によって測定されたアルコール消費・アルコール使用障害が「依存の可能性が高い」に分類された群と、Patient Centered Assessment Method(PCAM)によってスコア化された患者複雑性が関連していることを示しました。

  • Iwata H, Matsushima M, Watanabe T, Sugiyama Y, Yokobayashi K, Son D, Satoi Y, Yoshida E, Satake S, Hinata Y, Fujinuma Y. The need for home care physicians in Japan – 2020 to 2060. BMC Health Serv Res 2020;20(1):752.

概要:将来の日本に必要な在宅医の数を予測した研究です。

  • Aoki T, Fukuhara S. Associations of Types of Primary Care Facilities with Adult Vaccination and Cancer Screening in Japan. Int J Qual Health Care 2020 May 20. [Epub ahead of print].

概要:全国多施設研究のデータを用い、診療所がプライマリ・ケア医(Usual Source of Care)の患者と、中小病院がプライマリ・ケア医の患者を比較した結果、後者で予防医療(インフルエンザワクチン、肺炎球菌ワクチン、大腸癌検診)の実施が少ないことを報告しました。乳癌検診と子宮癌検診には有意差はありませんでした。病院プライマリ・ケアにおける予防医療強化の必要性が示唆されました。

  • Sato T, Sato S, Yamagami H, Komatsu T, Mizoguchi T, Yoshimoto T, Takagi M, Ihara M, Koga M, Iwata H, Matsushima M, Toyoda K, Iguchi Y. D-dimer level and outcome of minor ischemic stroke with large vessel occlusion. J Neurol Sci 2020 Mar 31; 413: 116814. [Epub ahead of print]

  • Hayashi T, Matsushima M, Wakabayashi H, Bito S. Association between delivery methods for enteral nutrition and physical status among older adults. BMC Nutr 2020 Jan 14; 6:2. doi: 10.1186/s40795-019-0318-3. eCollection 2020.

 

〜2019年業績

  1. Seki M, Fujinuma Y, Matsushima M, Joki T, Okonogi H, Miura Y, Ohno I. How a problem-based learning approach could help Japanese primary care physicians: a qualitative study.Int J Med Educ 2019 Dec 26; 10: 232-240.

  2. Kaneko M, Van Boven K, Takayanagi H, Kusaba T, Yamada T, Matsushima M. Multicentre descriptive cross-sectional study of Japanese home visit patients: reasons for encounter, health problems and multimorbidity. Fam Pract 2019 Oct 5. pii: cmz056. doi: 10.1093/fampra/cmz056. [Epub ahead of print]

  3. Yodoshi T, Matsushima M, Taniguchi T, Kinjo S. Utility of point-of-care Gram stain by physicians for urinary tract infection in children ≤36 months. Medicine (Baltimore) 2019 Apr; 98(14): e15101. doi: 10.1097/MD.0000000000015101.

  4. Yoshida S, Matsushima M, Wakabayashi H, Mutai R, Sugiyama Y, Yodoshi T, Horiguchi R, Watanabe T, Fujinuma Y. Correlation of patient complexity with the burden for health-related professions, and differences in the burden between the professions at a Japanese regional hospital: a prospective cohort study. BMJ Open 2019 Feb 21; 9(2): e025176. doi: 10.1136/bmjopen-2018-025176.

  5. Nakano Y, Matsushima M, Nakamori A, Hiroma J, Matsuo E, Wakabayashi H, Yoshida S, Ichikawa H, Kaneko M, Mutai R, Sugiyama Y, Yoshida E, Kobayashi T. Depression and anxiety in pet owners after a diagnosis of cancer in their pets: a cross-sectional study in Japan. BMJ Open 2019 Feb 19; 9(2): e024512. doi: 10.1136/bmjopen-2018-024512.

  6. Komatsu T, Iguchi Y, Arai A, Sakuta K, Sakai K, Terasawa Y, Mitsumura H, Matsushima M. Large but Nonstenotic Carotid Artery Plaque in Patients With a History of Embolic Stroke of Undetermined Source. Stroke 2018 Dec; 49(12): 3054-3056. doi: 10.1161/STROKEAHA.118.022986.

  7. Hayashi T, Matsushima M, Bito S, Kanazawa N, Inoue N, Luthe SK, Wee CC. Predictors Associated with Survival Among Elderly In-Patients Who Receive Cardiopulmonary Resuscitation in Japan: An Observational Cohort Study. J Gen Intern Med 2019 Feb; 34(2): 206-210. doi: 10.1007/s11606-018-4747-5. Epub 2018 Nov 27.

  8. Okonogi H, Kawamura T, Joh K, Koike K, Miyazaki Y, Ogura M, Tsuboi N, Hirano K, Matsushima M, Yokoo T, Horikoshi S, Suzuki Y, Yasuda T, Shirai S, Shibata T, Hattori M, Akioka Y, Katafuchi R, Hashiguchi A, Hisano S, Shimizu A, Kimura K, Maruyama S, Matsuo S, Tomino Y; Special IgA Nephropathy Study Group. A grading system that predicts the risk of dialysis induction in IgA nephropathy patients based on the combination of the clinical and histological severity. Clin Exp Nephrol 2019 Jan; 23(1): 16-25. doi: 10.1007/s10157-018-1657-0. Epub 2018 Oct 26. Review..

  9. Kaneko M, Motomura K, Mori H, Ohta R, Matsuzawa H, Shimabukuro A, Matsushima M. Gatekeeping function of primary care physicians under Japan's free-access system: a prospective open cohort study involving 14 isolated islands. Fam Pract 2019 Jul 31; 36(4): 452-459. doi: 10.1093/fampra/cmy084.

  10. Wakabayashi H, Matsushima M, Momosaki R, Yoshida S, Mutai R, Yodoshi T, Murayama S, Hayashi T, Horiguchi R, Ichikawa H. The effects of resistance training of swallowing muscles on dysphagia in older people: A cluster, randomized, controlled trial. Nutrition 2018 Apr; 48:111-116. doi: 10.1016/j.nut.2017.11.009. Epub 2017 Nov 2.

  11. Hirayama Y, Otani T, Matsushima M . Japanese citizens' attitude toward end-of-life care and advance directives: A qualitative study for members of medical cooperatives. J Gen Fam Med 2017 Jul 26; 18(6): 378-385. doi: 10.1002/jgf2.100. eCollection 2017 Dec.

  12. Kaneko M, Ohta R, Nago N, Fukushi M, Matsushima M. Correlation between patients' reasons for encounters/health problems and population density in Japan: a systematic review of observational studies coded by the International Classification of Health Problems in Primary Care (ICHPPC) and the International Classification of Primary care (ICPC). BMC Fam Pract 2017 Sep 13; 18(1): 87. doi: 10.1186/s12875-017-0658-5. Review.

  13. Narui R, Tokuda M, Matsushima M, Isogai R, Tokutake K, Yokoyama K, Hioki M, Ito K, Tanigawa SI, Yamashita S, Inada K, Shibayama K, Matsuo S, Miyanaga S, Sugimoto K, Yoshimura M, Yamane T. Incidence and Factors Associated With the Occurrence of Pulmonary Vein Narrowing After Cryoballoon Ablation.Circ Arrhythm Electrophysiol. 2017 Jun; 10(6). pii: e004588. doi: 10.1161/CIRCEP.116.004588.

  14. Yoshida S, Matsushima M, Wakabayashi H, Mutai R, Murayama S, Hayashi T, Ichikawa H, Nakano Y, Watanabe T, Fujinuma Y. Validity and reliability of the Patient Centred Assessment Method for patient complexity and relationship with hospital length of stay: a prospective cohort study. BMJ Open. 2017 May 9; 7(5): e016175. doi: 10.1136/bmjopen-2017-016175.

  15. Kaneko M, Matsushima M, Irving G. The ecology of medical care on an isolated island in Okinawa, Japan: a retrospective open cohort study. BMC Health Serv Res 2017 Jan 14; 17(1): 37. doi: 10.1186/s12913-017-1979-8.

  16. Dobashi A, Goda K, Yoshimura N, Ohya TR, Kato M, Sumiyama K, Matsushima M, Hirooka S, Ikegami M, Tajiri H. Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy. World J Gastroenterol 2016 Nov 7; 22(41): 9196-9204.

  17. Watanabe T, Matsushima M, Nagata T, Tominaga T, Yokoyama H, Fujinuma Y. Evaluation of the Diabetes Chronic-care System in Japanese Clinics. Jikeikai Medical Journal. 2016; 63(3): 63-70.

  18. Yamamoto T, Miyazaki M, Nakayama M, Yamada G, Matsushima M, Sato M, Sato T, Taguma Y, Sato H, Ito S. Erratum to: Impact of hemoglobin levels on renal and non-renal clinical outcomes differs by chronic kidney disease stages: the Gonryo study. Clin Exp Nephrol. 2017 Dec; 21(6): 1140. doi: 10.1007/s10157-017-1435-4.

  19. 金子 惇, 松島雅人. 高次医療機関へのアクセスが制限された地域でのICPC-2を用いた年齢別の受診理由及び健康問題に関する後ろ向きコホート研究. 日本プライマリ・ケア連合学会誌. 2016; 39(3): 144-149.

  20. Shiba H, Hashimoto K, Kelly D, Fujiki M, Quintini C, Aucejo F, Uso TD, Yerian L, Yanaga K, Matsushima M, Eghtesad B, Fung J, Miller C. Risk stratification of allograft failure secondary to hepatitis C recurrence after liver transplantation. Hepatol Res 2016 Oct; 46(11): 1099-1106. doi: 10.1111/hepr.12661. Epub 2016 Mar 6.

  21. Wakabayashi H, Matsushima M, Uwano R, Watanabe N, Oritsu H, Shimizu Y. Skeletal muscle mass is associated with severe dysphagia in cancer patients.J Cachexia Sarcopenia Muscle 2015 Dec; 6(4): 351-7. doi: 10.1002/jcsm.12052.

  22. Yamamoto T, Miyazaki M, Nakayama M, Yamada G, Matsushima M, Sato M, Sato T, Taguma Y, Sato H, Ito S. Impact of hemoglobin levels on renal and non-renal clinical outcomes differs by chronic kidney disease stages: the Gonryo study. Clin Exp Nephrol 2016 Aug;20(4): 595-602. doi: 10.1007/s10157-015-1190-3.

  23. Seki N, Sugita T, Aida Y, Itagaki M, Ishiguro H, Sutoh S, Abe H, Tsubota A, Matsushima M, Aizawa Y. Assessment of the features of serum apolipoprotein profiles in chronic HCV infection: difference between HCV genotypes 1b and 2. Hepatol Int 2014 Oct; 8(4): 550-9. doi: 10.1007/s12072-014-9572-2.

  24. Yamamoto T, Nakayama M, Miyazaki M, Matsushima M, Sato T, Taguma Y, Sato H, Ito S. Relationship between low blood pressure and renal/cardiovascular outcomes in Japanese patients with chronic kidney disease under nephrologist care: the Gonryo study. Clin Exp Nephrol 2015 Oct; 19(5): 878-86. doi: 10.1007/s10157-015-1084-4.

  25. Tominaga T, Matsushima M, Nagata T, Moriya A, Watanabe T, Nakano Y, Hirayama Y, Fujinuma Y. Psychological impact of lifestyle-related disease disclosure at general checkup: a prospective cohort study. BMC Fam Pract 2015 May 14; 16:60. doi: 10.1186/s12875-015-0272-3.

  26. Kinoshita A, Onoda H, Imai N, Iwaku A, Oishi M, Tanaka K, Fushiya N, Koike K, Nishino H, Matsushima M. The C-reactive protein/albumin ratio, a novel inflammation-based prognostic score, predicts outcomes in patients with hepatocellular carcinoma. Ann Surg Oncol 2015 Mar; 22(3): 803-10. doi: 10.1245/s10434-014-4048-0. 

  27. Dobashi A, Goda K, Sumiyama K, Kobayashi M, Ohya TR, Kato M, Toyoizumi H, Kato T, Matsushima M, Tajiri H. A feasibility study of chemically assisted endoscopic submucosal mechanical dissection using mesna for superficial esophageal squamous cell carcinomas. Surg Endosc 2015 Nov; 29(11): 3373-81. doi: 10.1007/s00464-014-4031-7.

  28. Kawamura T, Yoshimura M(Kanazawa Medical Centre), Miyazaki Y, Okamoto H, Kimura K, Hirano K, Matsushima M, Utsunomiya Y, Ogura M, Yokoo T, Okonogi H, Ishii T, Hamaguchi A, Ueda H, Furusu A, Horikoshi S, Suzuki Y, Shibata T, Yasuda T, Shirai S, Imasawa T, Kanozawa K, Wada A, Yamaji I, Miura N, Imai H, Kasai K, Soma J, Fujimoto S, Matsuo S, Tomino Y; Special IgA Nephropathy Study Group. A multicenter randomized controlled trial of tonsillectomy combined with steroid pulse therapy in patients with immunoglobulin A nephropathy. Nephrol Dial Transplant 2014 Aug; 29(8): 1546-53. doi: 10.1093/ndt/gfu020. 

  29. Yokobayashi K, Matsushima M, Watanabe T, Fujinuma Y, Tazuma S. Prospective cohort study of fever incidence and risk in elderly persons living at home. BMJ Open 2014 Jul 9; 4(7):e004998. doi:  10.1136/bmjopen-2014-004998.

  30. Yokobe J, Kitahara M, Matsushima M, Uezono S. Preference for different anchor descriptors on visual analogue scales among Japanese patients with chronic pain. PLoS One 2014 Jun 13; 9(6): e99891. doi: 10.1371/journal.pone.0099891. eCollection 2014.PMID: 24927424.

  31. Kinoshita A, Onoda H, Imai N, Iwaku A, Oishi M, Tanaka K, Fushiya N, Koike K, Nishino H, Matsushima M, Tajiri H. The addition of C-reactive protein to validated staging systems improves their prognostic ability in patients with hepatocellular carcinoma. Oncology 2014; 86(5-6): 308-17. doi: 10.1159/000360704.

  32. Wakabayashi H, Sashika H, Matsushima M. Head lifting strength is associated with dysphagia and malnutrition in frail older adults. Geriatr Gerontol Int 2014 Apr 1. doi: 10.1111/ggi.12283. 

  33. Kawasaki A, Matsushima M, Miura Y, Watanabe T, Tominaga T, Nagata T, Hirayama Y, Moriya A, Nomura K. Recognition of and intent to use gastrostomy or ventilator treatments in older patients with advanced dementia: Differences between laypeople and healthcare professionals in Japan. Geriatr Gerontol Int. 2014 Mar 20.  doi: 10.1111/ggi.12276. 

  34. Kinoshita A, Onoda H, Imai N, Iwaku A, Oishi M, Tanaka K, Fushiya N, Koike K, Nishino H, Matsushima M, Tajiri H. Elevated plasma fibrinogen levels are associated with a poor prognosis in patients with hepatocellular carcinoma.Oncology. 2013; 85(5): 269-77. doi: 10.1159/000355502. 

  35. Tani Y, Nakayama M, Tanaka K, Hayashi Y, Asahi K, Kamata T, Ogihara M, Sato K, Matsushima M, Watanabe T. Blood pressure elevation in hemodialysis patients after the Great East Japan Earthquake. Hypertens Res. 2014 Feb; 37(2): 139-44. doi: 10.1038/hr.2013.116. 

  36. Miyazaki Y, Kawamura T, Joh K, Okonogi H, Koike K, Utsunomiya Y, Ogura M, Matsushima M, Yoshimura M, Horikoshi S, Suzuki Y, Furusu A, Yasuda T, Shirai S, Shibata T, Endoh M, Hattori M, Akioka Y, Katafuti R, Hashiguchi A, Kimura K, Matsuo S, Tomino Y.Clin Exp Nephrol. Overestimation of the risk of progression to end-stage renal disease in the poor prognosis' group according to the 2002 Japanese histological classification for immunoglobulin A nephropathy. Clin Exp Nephrol. 2014 Jun; 18(3): 475-80. doi: 10.1007/s10157-013-0848-y.

  37. Ogawa S, Matsushima M, Mori T, Okamura M, Senda M, Sakamoto T, Nako K, Ito S. Identification of the Stages of Diabetic Nephropathy at Which Angiotensin II Receptor Blockers Most Effectively Suppress Albuminuria. Am J Hypertens. 2013 Sep; 26(9): 1064-9. doi: 10.1093/ajh/hpt085.

  38. Sakai T, Shikishima K, Matsushima M, Tsuneoka H. Genetic polymorphisms associated with endothelial function in nonarteritic anterior ischemic optic neuropathy. Mol Vis. 2013; 19: 213-9. 

  39. Kinoshita A, Onoda H, Imai N, Iwaku A, Oishi M, Tanaka K, Fushiya N, Koike K, Nishino H, Matsushima M, Saeki C, Tajiri H. The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma. BMC Cancer 2013 Feb 2; 13:52. doi: 10.1186/1471-2407-13-52.

  40. Yokobayashi K, Matsushima M, Fujinuma Y, Tazuma S. Retrospective cohort study of the incidence and risk of fever in elderly people living at home: A pragmatic aspect of home medical management in Japan. Geriatr Gerontol Int. 2013 Jan 7. doi: 10.1111/ggi.12024. 

  41. Sekiyama H, Nagoshi T, Komukai K, Matsushima M, Katoh D, Ogawa K, Minai K, Ogawa T, Yoshimura M. Transient decrease in serum potassium level during ischemic attack of acute coronary syndrome: paradoxical contribution of plasma glucose level and glycohemoglobin. Cardiovasc Diabetol. 2013 Jan 4; 12:4. doi: 10.1186/1475-2840-12-4.

  42. Terawaki H, Nakayama M, Miyazawa E, Murata Y, Nakayama K, Matsushima M, Miyazaki M, Sato H, Sato M, Sato T, Taguma Y, Ito S: Erratum to: Effect of allopurinol on cardiovascular incidence among hypertensive nephropathy patients: the Gonryo study. Clin Exp Nephrol. 2013;17(4): 554.

  43. Hirano K, Kawamura T, Tsuboi N, Okonogi H, Miyazaki Y, Ikeda M, Matsushima M, Hanaoka K, Ogura M, Utsunomiya Y, Hosoya T. The predictive value of attenuated proteinuria at 1 year after steroid therapy for renal survival in patients with IgA nephropathy. Clin Exp Nephrol. 2013 Aug; 17(4): 555-62. doi: 10.1007/s10157-012-0744-x. 

  44.  Terawaki H, Nakayama M, Miyazawa E, Murata Y, Nakayama K, Matsushima M, Miyazaki M, Sato H, Sato M, Sato T, Taguma Y, Ito S: Effect of allopurinol on cardiovascular incidence among hypertensive nephropathy patients: the Gonryo study. Clin Exp Nephrol. 2013;17(4):549-553.

  45. Watanabe K, Tani Y, Kimura H, Tanaka K, Hayashi Y, Asahi K, Sato K, Sato M, Matsushima M, Nakayama M, Watanabe T. Clinical outcomes of Japanese MPO-ANCA-related nephritis: significance of initial renal death for survival. Intern Med. 2012; 51(15): 1969-76. 

  46. Kurosawa S, Matsushima M, Fujinuma Y, Hayashi D, Noro I, Kanaya T, Watanabe T, Tominaga T, Nagata T, Kawasaki A, Hosoya T, Yanagisawa H. Two principal components, coping and independence, comprise patient enablement in Japan: cross sectional study in tohoku area. Tohoku J Exp Med. 2012. Jun;227(2): 97-104.

  47. 坂戸慶一郎, 松島雅人, 川﨑彩子, 横田祐介, 岩上真吾, 佐藤裕美, 田中 忍, 平塚祐介, 竹内一仁. 地域病院における経皮内視鏡胃瘻増設術(PEG)の長期生命予後―後ろ向きコホート研究. 日本プライマリ・ケア連合学会誌 2012; 35(2): 104-108.

  48. Kawamura T, Joh K, Okonogi H, Koike K, Utsunomiya Y, Miyazaki Y, Matsushima M, Yoshimura M, Horikoshi S, Suzuki Y, Furusu A, Yasuda T, Shirai S, Shibata T, Endoh M, Hattori M, Akioka Y, Katafuchi R, Hashiguchi A, Kimura K, Matsuo S, Tomino Y, Study Group SI. A histologic classification of IgA nephropathy for predicting long-term prognosis: emphasis on end-stage renal disease. J Nephrol. 2013 Mar-Apr; 26(2): 350-7. doi: 10.5301/jn.5000151. 

  49. Hosoya T, Matsushima M, Nukariya K, Utsunomiya K. The relationship between the severity of depressive symptoms and diabetes-related emotional distress in patients with type 2 diabetes. Intern Med. 2012 Feb; 51(3): 263-9.

  50. Date T, Yamane T, Yamashita S, Matsuo S, Matsushima M, Inada K, Taniguchi I, Yoshimura M. Paradoxical clearance of natriuretic peptide between pulmonary and systemic circulation: A pulmonary mechanism of maintaining natriuretic peptide plasma concentration in obese individuals. J Clin Endocrinol Metab. 2012 Jan; 97(1): 14-21.

  51. Hayashi N, Matsushima M, Yamamoto T, Sasaki H, Takahashi H, Egawa S. The impact of hypertriglyceridemia on prostate cancer development in patients aged ≥60 years. BJU Int. 2012 Feb; 109(4): 515-9.

  52. Nakayama M, Sato T, Miyazaki M, Matsushima M, Sato H, Taguma Y, Ito S. Increased risk of cardiovascular events and mortality among non-diabetic chronic kidney disease patients with hypertensive nephropathy: the Gonryo study. Hypertens Res. 2011 Oct; 34(10): 1106-10.

  53. Yokoyama H, Matsushima M, Kawai K, Hirao K, Oishi M, Sugimoto H, Takeda H, Minami M, Kobayashi M, Sone H, on behalf of Japan Diabetes Clinical Data Management Study Group. Law incidence of cardiovascular events in Japanese patients with type2 diabetes in primary care settings:a prospective cohort study. Diabet Med. 2011 Oct; 28(10): 1221-8.

  54. Inoue T, Kawai M, Nakane T, Nojiri A, Minai K, Komukai K, Ogawa T, Hongo T ,Matsushima M, and Yoshimura M. Influence of Low-Grade Inflammation on Plasma B-type Natriuretic Peptide Levels. Internal Medicine 2010; 49: 2659-68.

  55. Nakayama M, Sato T, Sato H, Yamaguchi Y, Obara K, Kurihara I, Sato K, Hotta O, Seino J, Miyata M, Takeuchi K, Nakayama K, Matsushima M, Otaka T, Kinoshita Y, Taguma Y and Ito S. Different clinical outcomes for cardiovascular events and mortality in chronic kidney disease according to underlying renal disease: the Gonryo study. Clinical and Experimental Nephrology 2010:14; 333-339.

  56. Ogawa S, Nakayama K, Nakayama M, Mori T, Matsushima M, Okamura M, Senda M, Nako K, Miyata T, Ito S. Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure.Hypertension. 2010 Sep; 56(3): 471-6. 

  57. 黒澤聡子, 松島雅人, 三浦靖彦, 野村幸史. 内科外来のうち「初診・予約外外来」を「総合診療外来」へ改称した前後での受診理由の変化. 日本プライマリ・ケア連合学会 2010; 33; 238-245.

  58. Sato M, Yamadera W, Matsushima M, Itoh H, Nakayama K. Clinical efficacy of individual cognitive behavior therapy for psychophysiological insomnia in 20 outpatients.Psychiatry Clin Neurosci. 2010 Apr; 64(2): 187-95.

  59. Kurita A, Murakami M, Takagi S, Matsushima M, Suzuki M. Visual hallucinations and altered visual information processing in Parkinson disease and dementia with Lewy bodies. Movement Disorders 2010; 25: 167-171.

  60. 川畑奈緒, 松島雅人, 湯浅愛, 藤山康広, 田嶼尚子. 2型糖尿病患者における食行動の偏りと栄養素摂取量および食品群別摂取量との関連. 糖尿病 2009; 52: 757-765.

  61. Mamori S, Matsushima M, Matsuura T, Tajiri H. Survivin is expressed in early hepatocellular carcinoma and surrounding hepatitis tissue. Mol Med Report 2009, 2: 911-915.

  62. 野村泰之, 五十嵐眞, 須藤正道, 肥田和恵, 関口千春, 石井正則, 松島雅人, 兼板佳孝, 池田稔. 7日間ベッドレスト実験における視運動性眼振および後眼振の適応動態. 宇宙航空環境医学 45: 3-9, 2008.

  63. Mamori S, Searashi Y, Matsushima M, Hashimoto K, Uetake S, Matsudaira H, Ito S, Nakajima H, Tajiri H. Serum type IV collagen level is predictive for esophageal varices in patients with severe alcoholic disease. World Journal of Gastroenterology  2008; 14: 2044-2048.

  64. Mohri J, Yoshizawa Y, Kanke M, Matsuyama K, Ishibashi Y, Suzuki Y, Kashiwagi H, Kobayashi M, Kanehira C, Matsushima M, Ichiba T, Arakawa Y, Inoue D, Sakuyama T, Kobayashi T, Aiba K. Correlation between Serum Albumin and Myelosupression in Patients with Esophagial Cancer Treated with Chemoradiation Therapy. Jikeikai Med J 2008 ; 55(1): 7-14.

  65. 福住曜子, 谷  諭, 磯島 晃, 長島弘泰, 阿部俊昭, 松島雅人. キアリ1型奇形に伴う脊髄空洞症―治療効果に関与する因子の検討―. 脊髄外科  2007; 21: 123-130.

  66. Sakai T, Matsushima M, Shikishima K, Kitahara K. Comparison of standard automated perimetry with Matrix frequency-doubling technology in patients with resolved optic neuritis. Ophthalmology  2007; 114: 949-956.

  67. Sakai T, Shikishima K, Matsushima M, Kitahara K. Endothelial nitric oxide synthase gene polymorphisms in non-arteritic anterior ischemic optic neuropathy. Graefe’s Arch Clin Exp Ophthalmol  2007; 245: 288-292.

  68. Nakagawa K, Ishibashi T, Matsushima M, Tanifuji Y, Amaki Y, Furuhata H. Does long-term continuous transcranial doppler monitoring requires a pause for safer use? Cerebrovasc Dis 2007; 24: 27-34.

  69. Mamori S,, Nagatsuma K, Matsuura T, Ohkawa K, Hano H, Fukunaga M, Matsushima M, Masui Y, Fushiya N, Onoda H, Searashi Y, Takagi I and Tajiri H. Usefule detection of CD147(EMMPRIN) for pathological diagnosis of early hepatocellular carcinoma in needle biopsy sample. World J Gastroenterol 2007; 13: 2913-2917.

  70. 古賀祥嗣, 平松 信, 中山昌明, 中元秀友, 中野広文, 政金生人, 伊丹儀友, 伊東 稔, 稲熊大城, 河合弘進, 笠原正登, 吉元和浩, 宮形 滋, 栗山 哲, 山中正人, 山本裕康, 小坂直之, 小倉 誠, 松田 香, 久保義広, 上村寛和, 清野耕治, 西田英一, 石橋由孝, 石崎 允, 石田真理, 川原和彦, 川根隆志, 足立陽子, 池添正哉, 竹田正廣, 中岡明久, 田畑 勉, 藤島幹彦, 畠中建策, 樋口千惠子, 有薗健二, 林晃正, 鈴木勝雄, 松島雅人. 新たな展開をみせる高齢者の腹膜透析 高齢者PDの実態調査(第四報). 腎と透析 2006;61(別冊): 47-51.

  71. 横山宏樹, 蔵光雅恵, 横田友紀, 多田純子, 上川二代, 菅野咲子, 松島雅人. 2型糖尿病におけるピオグリタゾンとアカルボースの併用による抗動脈硬化効果. 糖尿病2006; 49: 197-204.

  72. Sakai T, Kohno H, Ishihara T, Higaki M, Saito S, Matsushima M, Mizushima Y and Kitahara K. Treatment of experimental autoimmune uveoretinitis with poly(lactic acid) nanoparticles encapsulating betamethasone phosphate. Experimental Eye Research 2006; 82: 657-63.

  73. Miura Y, Asai A, Matsushima M, Nagata S, Onishi M, Shimbo T,  Hosoya T and Fukuhara S. Families’ and Physicians’ Predictions of Dialysis Patients’ Preferences Regarding Life-Sustaining Treatments in Japan. American Journal of Kidney Diseases 2006; 47: 122-30.

  74. Yamamoto R, Otsuka Y, Nakayama M, Maruyama Y, Katoh N, Ikeda M, Yamamoto H, Yokoyama K, Kawaguchi Y, and Matsushima M. Risk factor for encapsulating peritoneal sclerosis in patients who have experienced pritoneal dialysis treatment. Clin Exp Nephrol 2005; 9: 148-152.

  75. Misawa T, Sakurai M, Kanai H, Matsushima M, Yamazaki Y and Yanaga K. Kugel herniorrhaphy: clinical results of 124 consecutive operations. Surg Today 2005; 35: 639-44.

  76. 松尾七重, 梁 鐘五, 木村弘明, 近藤 誠, 濱口明彦, 加藤尚彦, 横山啓太郎, 中山昌明, 松島雅人, 細谷龍男. 腹膜炎とカテーテル感染/その他の合併症 腹膜透析患者の生命予後に対する導入時因子の影響について. 腎と透析, 57: 343-346, 2004.

  77. 古賀祥嗣, 平松 信, 中山昌明, 政金生人, 中野広文, 石田真理, 伊丹儀友, 鈴木勝雄, 宮形滋, 石崎 允, 伊東 稔, 河合弘進, 池添正哉, 小倉 誠, 樋口千惠子, 松田 香, 原 相俊, 稲熊大城, 竹田正廣, 川根隆志, 林 晃正, 足立陽子, 笠原正登, 中岡明久, 川原和彦, 山中正人, 西田英一, 有薗健二, 久保義広, 吉元和浩, 上村寛和, 松島雅人. 高齢者PDをより良くするために 高齢者PDの実態調査報告. 腎と透析, 57: 35-38, 2004.

  78. 上原 好, 宇都宮一典, 蒲池桂子, 吉原理恵, 谷口幹太, 横田太持, 蔵田英明, 松島雅人, 田嶼尚子. 糖尿病性腎症患者における摂取蛋白量の簡易指標の検討. 糖尿病 2004; 47:291-295.

  79. 橋本博子, 中崎 薫, 根岸道子, 鳥居 明, 和田高士, 松島雅人. 胃食道逆流症に及ぼす嗜好品の影響に関する研究. 慈恵医大誌 2004; 119: 77-85.

  80. Masaki E, Saito H, Shoji K, Matsushima M. Postoperative analgesic effect of epidural neostigmine and plasma cortisol and IL-6 responses. J Clin Anesth 2004; 16: 488-92.

  81. Terawaki H, Yoshimura K, Hasegawa T, Matsuyama Y, Negawa T, Yamada K, Matsushima M, Nakayama M, Hosoya T, Era S. Oxidative stress is enhanced in correlation with renal dysfunction: Examination with the redox state of albumin. Kidney International 2004; 66: 1988-93.

  82. 伊藤正臣, 中野 匠, 高橋現一郎, 松島雅人, 北原健二. 非穿孔性線維柱帯切除およびサイヌソトミーを併用した線維柱帯切開術の術後4年の成績. 眼科手術 2004; 17: 557-62.

  83. 植松昌俊, 松島雅人. 慢性疾患における睡眠習慣,睡眠覚醒障害に関する臨床的研究. 総合病院精神医学 2004; 16: 24-34.

  84. Uchigata Y, Asao K, Matsushima M, Sato A, Yokoyama H, Otani T,Kasahara T, Takaike H, Okudaira M, Miura J, Maruyama H, Iwamoto Y. Impact on mortality and incidence of end-stage renal disease of education and treatment at a diabetes center among patients with type 1 diabetes: comparison of two subgroups in the Japanese DERI cohort. J Diabetes Complications 2004; 18: 155-9.

  85. 田嶼尚子, 松島雅人, 松岡健平, 河盛隆造, 岩本安彦, 赤沼安夫, 東京糖尿病合併症研究会. 首都圏糖尿病患者における糖尿病性神経障害の実態調査. 糖尿病 2003; 46: 301-10.

  86. Nakazaki K,Hashimoto H,Torii A,Kurisu A,Wada T,Matsushima M. Correlation of Reflux Esophagitis and Obesity: Quantitative and Qualitative Analysis. Jikeikai Med J 2003; 50: 167-72.

  87. Ishibashi Y. Hanyu N. Nakada K. Suzuki Y. Yamamoto T. Takahashi T. Kawasaki N. Kawakami M. Matsushima M. Urashima M. Endothelin protein expression as a significant prognostic factor in oesophageal squamous cell carcinoma. Eur J Cancer 2003; 39: 1409-15.

  88. Ishibashi Y. Hanyu N. Nakada K. Suzuki Y. Yamamoto T. Yanaga K. Ohkawa K. Hashimoto N. Nakajima T. Saito H. Matsushima M. Urashima M. Profiling gene expression ratios of paired cancerous and normal tissue predicts relapse of esophageal squamous cell carcinoma. Cancer Research 2003; 63: 5159-64.

  89. Asao K, Matsushima M, Marumo K, Uchida M, Shimizu H. Prognosis after Lower Extremity Amputation in Patients with Diabetes. Jikeikai Med J 2003; 50: 131-40.

  90. Asao K, Sarti C, Forsen T, Hyttinen V, Nishimura R, Matsushima M, Reunanen A, Tuomilehto J, Tajima N. Long-Term Mortality in Nationwide Cohorts of Childhood-Onset Type 1 Diabetes in Japan and Finland. Diabetes Care 2003; 26: 2037-42.

  91. 大畑 充, 坂本和彦, 鈴木英明, 橋本健一, 中島尚登, 戸田剛太郎, 松島雅人, 法橋 建. 当院における肝膿瘍40例の臨床疫学的検討 細菌性肝膿瘍とアメーバ性肝膿瘍の比較. 胆と膵, 24: 371-375, 2003.

  92. Kurosaka D, Yoshida K, Yasuda J, Yokoyama T, Kingetsu I, Yamaguchi N, Joh K, Matsushima M, Saito S, Yamada A. Inhibition of arthritis by systemic administration of endostatin in passive murine collagen induced arthritis. Annals of the Rheumatic Diseases 2003; 62: 677-9.

  93. 佐野浩斎, 宇都宮一典, 蔵田英明, 松島雅人, 縣  俊彦, 清水英佑, 田嶼尚子ほか. 糖尿病早期腎症に対するプロブコールの有用性の検討. Therapeutic Research 2002; 23: 1487-95.

  94. 佐野浩斎, 浅尾啓子, 松島雅人, 縣  俊彦, 清水英佑, 田嶼尚子ほか. 糖尿病患者におけるQuality of Life評価の試み(第2報)-Quality of Lifeに影響を与える患者背景因子と合併症-. 糖尿病 2001; 44: 57-62.

  95. 浅尾啓子, 松島雅人, 佐野浩斎, 縣  俊彦, 清水英佑, 田嶼尚子. 糖尿病患者におけるQuality of Life評価の試み(第1報)-DQOL(Diabetes Quality of Life)スケールを用いた基礎的検討. 糖尿病 2000; 43: 1085-91.

  96. The Global Lower Extremity Amputation Study Group.  Epidemiology of lower extremity amputation in certres in Europe,  North America and East Asia. Br J Surg 2000; 87: 328-37.

  97. 一之瀬万紀子, 池上雅博, 松島雅人, 鈴木博昭, 牛込新一郎.  大腸sm癌におけるリンパ節・肝転移の危険因子に関する臨床病理学的検討. Gastroenterol Endosc 1999; 41: 1163-74.

  98. Nishimura R, Tajima N, Matsushima M, LaPorte RE. Puberty, IDDM, and death in Japan. Diabetes Epidemiology Research International Study Group. Diabetes Care 1998; 21: 1674-9.

  99. Matsushima M, LaPorte RE, Maruyama M, Shimizu K, Nishimura R, Tajima N, et al. Geographic variation in mortality among individuals with youth-onset diabetes mellitus across the world. Diabetologia 1997; 40: 212-6.

  100. Nishimura R, Matsushima M, Tajima N, Agata T, Shimizu K, LaPorte RE et al. A major improvement in the prognosis of individuals with IDDM in the past 30 years in Japan. Diabetes Care 1996; 19: 758-60.

  101. Matsushima M, Shimizu K, Maruyama M, Nishimura R, LaPorte RE, Tajima N, et al. Socioeconomic and behavioural risk factors for mortality of individuals with IDDM in Japan: population-based case-control study. Diabetologia 1996; 39: 710-6.

  102. Diabetes Epidemiology Research International (DERI) Study. International analysis of insulin-dependent diabetes mellitus mortality: a preventable mortality perspective. Am J Epidemiol 1995; 142: 612-8.

  103. Bando K, Paradis IL, Komatsu K, Konishi H, Matsushima M, Keena RJ, et al. Analysis of time-dependent risks for infection, rejection, and death after pulmonary transplantation. J Thorac Cardiovasc Surg 1995; 109: 49-57.

  104. Matsushima M, Tajima N, LaPorte RE, Orchard T, Tull E, Gower I, et al. Markedly increased renal disease mortality and incidence of renal replacement therapy among IDDM patients in Japan in contrast to Allegheny County, Pennsylvania, USA. Diabetologia 1995; 38: 236-43.

  105. DiaMond Project Group on Social Issues. Global regulations on diabetics treated with insulin and their operation of commercial motor vehicles. Br Med J 1993; 307: 250-3.

  106. 春日伸予, 田嶼尚子, 松島雅人, 北川照男, LaPorte RE,DERI研究班. 小児期発症IDDMの居住地の地域特性と生命予後との関係. 糖尿病 1992; 35: 391-6.

  107. 松島雅人, 田嶼尚子, 横山淳一, 池田義雄, 磯貝行秀, 縣  俊彦, 吉葉繁雄. IDDMの血清immunoreactive trypsin値に関与する環境及び遺伝因子の影響について. 糖尿病 1991; 34: 335-41.

  108. 松島雅人. 若年発症糖尿病患者の社会経済的背景に関する研究: ケースコントロール研究. 慈恵医大誌 1991; 106: 913-22.

  109. 春日伸予, 田嶼尚子, 松島雅人, 縣  俊彦, 北川照男, LaPorte REほか. 小児期発症IDDMの生命予後と医療体制との関連. 糖尿病 1991; 34:31-6.

  110. Diabetes Epidemiology Research International Mortality Study Group.  Major cross-difference in risk of dying for people with IDDM. Diabetes Care 1991;14: 49-54.

  111. Diabetes Epidemiology Research International Mortality Study Group.  International evaluation of cause-specific mortality and IDDM. Diabetes Care 1991; 14: 55-60.

  112. 松島雅人, 田嶼尚子, 横山淳一, 池田義雄, 磯貝行秀, 縣  俊彦, 松本信雄. IDDMの膵B細胞機能残存性に関与する環境および遺伝因子の影響について. 糖尿病 1990; 33: 53-8.

 

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